SCHEMBL8628801

SCHEMBL8628801

N#Cc1ccc(C(=O)NP(N)(N)=O)s1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 1/20 0.45
S1PR1 P21453 2/20 0.44
S1PR3 Q99500 2/20 0.44
S1PR2 O95136 1/20 0.44
S1PR4 O95977 1/20 0.44
HPGDS O60760 2/20 0.35
ALDH1A1 P00352 2/20 0.33
KMT2A Q03164 2/20 0.33
HDAC3 O15379 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC1 Q13547 1/20 0.33
RAB9A P51151 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
INSR P06213 1/20 0.32
ITK Q08881 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
ESRRG P62508 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.31
POLB P06746 2/20 0.30
MEN1 O00255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10935147 0.82 HDAC1 (0.43) HDAC8HPGDSALDH1A1KMT2AHDAC3
SCHEMBL20786824 0.77 KDM4E (0.49) HDAC8S1PR1S1PR3S1PR2S1PR4
SCHEMBL12670964 0.77 S1PR1 (0.50) HDAC8S1PR1S1PR3S1PR2S1PR4
SCHEMBL7205892 0.74 F2 (0.52) HDAC8S1PR1S1PR3S1PR2S1PR4
SCHEMBL8632018 0.74 GAA (0.54) ALDH1A1KMT2ARAB9ASMN1; SMN2L3MBTL1
SCHEMBL8629681 0.74 F2 (0.57) ALDH1A1KMT2ARAB9ASMN1; SMN2MEN1
SCHEMBL6375945 0.74 KMT2A (0.53) ALDH1A1KMT2ARAB9ASMN1; SMN2L3MBTL1
SCHEMBL8630276 0.74 HDAC6 (0.55) ALDH1A1KMT2AHDAC3HDAC4HDAC1
SCHEMBL12677420 0.73 HDAC4 (0.54) HDAC8S1PR1S1PR3S1PR2S1PR4
SCHEMBL22099927 0.73 HDAC8 (0.45) HDAC8S1PR1S1PR3S1PR2S1PR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5840917-A ADMINISTERING TO MAMMAL TO ERADICATE HELICOBACTER PYLORI TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-11-24 US disclosed
WO-1998042347-A1 PHARMACEUTICAL COMPOSITION CONTAINING A PHOSPHORYLAMIDE AND AN AYNTIBIOTIC TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-10-01 WO disclosed
EP-0852498-A1 PHOSPHORYLAMIDES, THEIR PREPARATION AND USE Takeda Chemical Industries, Ltd. (JP) 1998-07-15 EP disclosed
WO-1997011705-A1 PHOSPHORYLAMIDES, THEIR PREPARATION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-04-03 WO disclosed