SCHEMBL8630276

SCHEMBL8630276

CC(=O)c1ccc(C(=O)NP(N)(N)=O)s1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 4/20 0.55
GSK3B P49841 1/20 0.46
LMNA P02545 3/20 0.43
TSHR P16473 1/20 0.43
HDAC4 P56524 4/20 0.41
HDAC1 Q13547 4/20 0.41
HDAC3 O15379 3/20 0.41
MAPT P10636 3/20 0.39
ALDH1A1 P00352 3/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
KDM4E B2RXH2 2/20 0.39
GLA P06280 1/20 0.39
GAA P10253 1/20 0.39
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
POLB P06746 2/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2A6 P11509 1/20 0.36
CYP2C9 P11712 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10935147 0.90 HDAC1 (0.43) HDAC6HDAC4HDAC1HDAC3MAPT
SCHEMBL6375945 0.81 KMT2A (0.53) LMNAMAPTALDH1A1L3MBTL1KDM4E
SCHEMBL19316038 0.79 HDAC6 (0.56) HDAC6GSK3BLMNATSHRHDAC4
SCHEMBL8629681 0.78 F2 (0.57) GSK3BLMNATSHRMAPTALDH1A1
SCHEMBL8632018 0.78 GAA (0.54) GSK3BMAPTALDH1A1L3MBTL1KDM4E
SCHEMBL8627366 0.77 SMYD3 (0.54) LMNATSHRMAPTALDH1A1KDM4E
SCHEMBL8634109 0.77 SMN1; SMN2 (0.38) HDAC6GSK3BLMNAHDAC4HDAC1
SCHEMBL2872059 0.77 GSK3B (0.67) HDAC6GSK3BLMNATSHRMAPT
SCHEMBL6395252 0.76 KDM4E (0.55) HDAC6GSK3BLMNATSHRHDAC4
SCHEMBL8628158 0.76 NPSR1 (0.42) HDAC6LMNATSHRHDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5840917-A ADMINISTERING TO MAMMAL TO ERADICATE HELICOBACTER PYLORI TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-11-24 US disclosed
WO-1998042347-A1 PHARMACEUTICAL COMPOSITION CONTAINING A PHOSPHORYLAMIDE AND AN AYNTIBIOTIC TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-10-01 WO disclosed
EP-0852498-A1 PHOSPHORYLAMIDES, THEIR PREPARATION AND USE Takeda Chemical Industries, Ltd. (JP) 1998-07-15 EP disclosed
WO-1997011705-A1 PHOSPHORYLAMIDES, THEIR PREPARATION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-04-03 WO disclosed