Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10428831 | 0.83 | CA1 (0.53) | HPGDALDH1A1HTTLMNAMAPT | |
| SCHEMBL8627919 | 0.83 | TDP1 (0.53) | HPGDCES2CES1GSK3BALDH1A1 | |
| SCHEMBL8626139 | 0.81 | APP (0.55) | CES2CES1GSK3BALDH1A1ALOX15 | |
| SCHEMBL10428885 | 0.81 | APP (0.47) | CES2CES1HTTALOX15TSHR | |
| SCHEMBL3198121 | 0.81 | TSHR (0.52) | HPGDCES2CES1ALDH1A1ALOX15 | |
| SCHEMBL8625862 | 0.81 | HPGD (0.49) | HPGDHTTTSHRKDM4EMAPT | |
| SCHEMBL8630144 | 0.80 | ERCC5 (0.47) | HPGDALDH1A1ERCC5FEN1 | |
| SCHEMBL10429071 | 0.79 | APP (0.53) | HPGDALDH1A1HTTTSHRKDM4E | |
| SCHEMBL10428960 | 0.79 | PLK1 (0.49) | HPGDALDH1A1HTTALOX15TSHR | |
| SCHEMBL27978391 | 0.79 | SMN1; SMN2 (0.42) | HPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646570-B1 | PROCESS FOR PRODUCING LIGNAN COMPOUND | SHIONOGI & CO (JP) | 1998-06-24 | — | — | EP | disclosed |
| US-5488134-A | Preparation of compounds of lignan series | SHIONOGI & CO., LTD. (JP) | 1996-01-30 | — | — | US | disclosed |
| EP-0646570-A1 | PROCESS FOR PRODUCING LIGNAN COMPOUND | SHIONOGI & CO., LTD. (JP) | 1995-04-05 | — | — | EP | disclosed |
| US-4929741-A | ANTISECRETORY AGENTS, GASTRIC JUICE, ANTIULCER AGENTS | HOFFMAN-LA ROCHE INC. (US) | 1990-05-29 | — | — | US | disclosed |
| EP-0282898-A2 | Propiolophenone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-09-21 | — | — | EP | disclosed |