Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23484631 | 0.83 | TSHR (0.46) | HPGDTSHRKDM4EMAPTHTT | |
| SCHEMBL8628903 | 0.81 | HPGD (0.46) | HPGDTSHRKDM4EMAPTHTT | |
| SCHEMBL2879042 | 0.79 | TSHR (0.59) | TSHRKDM4EMEN1NPC1MAPT | |
| SCHEMBL8630144 | 0.79 | ERCC5 (0.47) | HPGDMEN1NPC1PKMRAB9A | |
| SCHEMBL5512015 | 0.77 | TSHR (0.58) | HPGDTSHRMEN1MAPTPKM | |
| SCHEMBL10428831 | 0.75 | CA1 (0.53) | HPGDNPC1MAPTPKMRAB9A | |
| SCHEMBL8627919 | 0.75 | TDP1 (0.53) | HPGDKDM4EMEN1NPC1MAPT | |
| SCHEMBL29822834 | 0.74 | ALDH1A1 (0.64) | HPGDTSHRKDM4EMEN1NPC1 | |
| SCHEMBL5393044 | 0.74 | ALDH1A1 (0.64) | HPGDTSHRKDM4EMEN1NPC1 | |
| SCHEMBL8626139 | 0.74 | APP (0.55) | NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646570-B1 | PROCESS FOR PRODUCING LIGNAN COMPOUND | SHIONOGI & CO (JP) | 1998-06-24 | — | — | EP | disclosed |
| US-5488134-A | Preparation of compounds of lignan series | SHIONOGI & CO., LTD. (JP) | 1996-01-30 | — | — | US | disclosed |
| CN-1109685-A | Process for producing lignan compound | SHIONOGI & CO (JP) | 1995-10-04 | — | — | CN | disclosed |
| EP-0646570-A1 | PROCESS FOR PRODUCING LIGNAN COMPOUND | SHIONOGI & CO., LTD. (JP) | 1995-04-05 | — | — | EP | disclosed |