Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.43 |
| ▸ | CHRNG | P07510 | 1/20 | 0.43 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.43 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8626440 | 0.82 | HDAC8 (0.50) | PARP1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL8628090 | 0.81 | CES2 (0.59) | PARP1NPC1RAB9AHPGDMEN1 | |
| SCHEMBL8628903 | 0.80 | HPGD (0.46) | ERCC5FEN1HPGDALDH1A1 | |
| SCHEMBL3198121 | 0.79 | TSHR (0.52) | ERCC5FEN1NPC1RAB9AHPGD | |
| SCHEMBL8625862 | 0.79 | HPGD (0.49) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL27426409 | 0.77 | LOXL2 (0.63) | NPC1RAB9ASMN1; SMN2CYP2C19PKM | |
| SCHEMBL642345 | 0.75 | RAB9A (0.59) | ERCC5FEN1PARP1NPC1RAB9A | |
| SCHEMBL29406761 | 0.75 | RAB9A (0.59) | ERCC5FEN1PARP1NPC1RAB9A | |
| SCHEMBL11544870 | 0.75 | GRM5 (0.48) | HPGDMEN1KMT2AGRM5KCNH2 | |
| SCHEMBL2057210 | 0.73 | ERCC5 (0.63) | ERCC5FEN1PARP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646570-B1 | PROCESS FOR PRODUCING LIGNAN COMPOUND | SHIONOGI & CO (JP) | 1998-06-24 | — | — | EP | disclosed |
| US-5488134-A | Preparation of compounds of lignan series | SHIONOGI & CO., LTD. (JP) | 1996-01-30 | — | — | US | disclosed |
| EP-0646570-A1 | PROCESS FOR PRODUCING LIGNAN COMPOUND | SHIONOGI & CO., LTD. (JP) | 1995-04-05 | — | — | EP | disclosed |