Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 4/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567153 | 0.92 | MAOB (0.48) | MRGPRX4PPARGNR4A2MAPK14PPIA | |
| SCHEMBL8625477 | 0.88 | MCL1 (0.48) | MRGPRX4PPARGNR4A2FFAR1FFAR4 | |
| SCHEMBL8630092 | 0.86 | MAPK14 (0.45) | MRGPRX4PPARGNR4A2MAPK14PPIA | |
| SCHEMBL6566122 | 0.85 | HDAC8 (0.51) | MRGPRX4PPARGPOLBMAPTKDM4E | |
| SCHEMBL7744003 | 0.80 | HDAC8 (0.57) | MRGPRX4POLBMAPTKDM4EALDH1A1 | |
| SCHEMBL8626364 | 0.79 | MEN1 (0.44) | MRGPRX4ALOX5MAPTKDM4EALDH1A1 | |
| SCHEMBL8629707 | 0.78 | MCL1 (0.51) | NR4A2KDM4EALDH1A1MAOB | |
| SCHEMBL6564097 | 0.78 | HDAC8 (0.50) | MRGPRX4PPARGMAPTKDM4EALDH1A1 | |
| SCHEMBL20067906 | 0.77 | PTGER1 (0.49) | MRGPRX4PPIAPOLBMAPT | |
| SCHEMBL8629713 | 0.77 | KMT2A (0.53) | MRGPRX4PPARGALOX5PPARAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |