Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CCR1 | P32246 | 2/20 | 0.45 |
| ▸ | CCR5 | P51681 | 2/20 | 0.45 |
| ▸ | CCR8 | P51685 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1905526 | 0.73 | NPC1 (0.47) | NPC1SMN1; SMN2TP53TSHRKDM4E | |
| SCHEMBL3596359 | 0.69 | NPC1 (0.56) | NPC1SMN1; SMN2TP53TSHRKDM4E | |
| Dipyridyl SCHEMBL6885910 | 0.68 | KDM4E (0.93) | NPC1SMN1; SMN2TP53TSHRKDM4E | |
| Dipyridyl SCHEMBL8655605 | 0.68 | KDM4E (0.93) | NPC1SMN1; SMN2TP53TSHRKDM4E | |
| SCHEMBL1445699 | 0.68 | KDM4E (0.50) | NPC1SMN1; SMN2TP53TSHRKDM4E | |
| SCHEMBL1544336 | 0.68 | NPC1 (0.55) | NPC1SMN1; SMN2TP53TSHRKDM4E | |
| SCHEMBL2474693 | 0.67 | NPC1 (1.00) | NPC1SMN1; SMN2TP53TSHRKDM4E | |
| SCHEMBL21893772 | 0.67 | NPC1 (0.48) | NPC1SMN1; SMN2TP53TSHRKDM4E | |
| Dipyridyl SCHEMBL27651116 | 0.66 | KDM4E (0.88) | NPC1SMN1; SMN2TP53TSHRKDM4E | |
| Dipyridyl SCHEMBL28760321 | 0.66 | KDM4E (0.88) | NPC1SMN1; SMN2TP53TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35754-E | FOR TREATING BACTERIAL INFECTIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-24 | — | — | US | disclosed |
| US-5710146-A | ANTIBIOTICS FOR BACTERICIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | disclosed |
| US-5089490-A | Cephem derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-18 | — | — | US | disclosed |
| US-4758556-A | Cephem derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-07-19 | — | — | US | disclosed |
| US-4399131-A | Cephem derivatives | HOECHST AG (DE) | 1983-08-16 | — | — | US | disclosed |
| US-4278793-A | ANTIBIOTICS, BACTERICIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-07-14 | — | — | US | disclosed |