Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HPD | P32754 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630905 | 0.96 | MAPT (0.50) | PLA2G4BMAPTLMNAMAPK1KMT2A | |
| SCHEMBL8699678 | 0.87 | MAPT (0.43) | PLA2G4BMAPTLMNAMAPK1KMT2A | |
| SCHEMBL8628560 | 0.84 | PTPN11 (0.60) | PLA2G4BMAPTPTPN11TP53TSHR | |
| SCHEMBL6564098 | 0.80 | AKR1C3 (0.47) | MAPTLMNAMAPK1SMN1; SMN2HPD | |
| SCHEMBL8381314 | 0.80 | MAPT (0.56) | PLA2G4BMAPTPTPN11LMNAMAPK1 | |
| SCHEMBL6564057 | 0.80 | PLA2G4B (0.49) | PLA2G4BMAPTPTPN11THRATHRB | |
| SCHEMBL6565647 | 0.79 | MAPT (0.55) | PLA2G4BMAPTPTPN11LMNAMAPK1 | |
| SCHEMBL10681005 | 0.79 | MAPT (0.58) | PLA2G4BMAPTLMNAMAPK1KMT2A | |
| SCHEMBL4255397 | 0.78 | TDP1 (0.55) | PLA2G4BMAPTLMNAMAPK1KMT2A | |
| SCHEMBL27719937 | 0.77 | MAPT (0.56) | PLA2G4BMAPTESR1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1120157-C | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | FIBER GENE CORP (US) | 2003-09-03 | — | — | CN | disclosed |
| CN-1282737-A | Intermediate product used for preparing substituted quinoline-2-formamide | MOECHST AG (DE) | 2001-02-07 | — | — | CN | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| CN-1154365-A | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | HOECHST AG (DE) | 1997-07-16 | — | — | CN | disclosed |