Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 5/20 | 0.43 |
| ▸ | THRB | P10828 | 5/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566280 | 0.97 | MAPT (0.48) | PLA2G4BMAPTLMNAMAPK1KMT2A | |
| SCHEMBL8633004 | 0.88 | MAPT (0.42) | PLA2G4BMAPTLMNAMAPK1KMT2A | |
| SCHEMBL8628560 | 0.82 | PTPN11 (0.60) | PLA2G4BMAPTPTPN11 | |
| SCHEMBL6564101 | 0.82 | SMN1; SMN2 (0.47) | MAPTLMNAMAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL6566219 | 0.80 | ALDH1A1 (0.41) | MAPTLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8629258 | 0.80 | PLA2G4B (0.51) | PLA2G4BMAPTPTPN11LMNAMAPK1 | |
| SCHEMBL4255397 | 0.78 | TDP1 (0.55) | PLA2G4BMAPTLMNAMAPK1KMT2A | |
| SCHEMBL6564212 | 0.78 | MEN1 (0.40) | MAPTLMNAKMT2ASMN1; SMN2THRB | |
| SCHEMBL6565266 | 0.78 | SIRT6 (0.45) | MAPTMAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL8381314 | 0.78 | MAPT (0.56) | PLA2G4BMAPTPTPN11LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| CN-1120157-C | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | FIBER GENE CORP (US) | 2003-09-03 | — | — | CN | disclosed |
| CN-1282737-A | Intermediate product used for preparing substituted quinoline-2-formamide | MOECHST AG (DE) | 2001-02-07 | — | — | CN | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| CN-1154365-A | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | HOECHST AG (DE) | 1997-07-16 | — | — | CN | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |