Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628003 | 0.89 | PTGS2 (0.49) | PTGS2LRRK2PTGS1 | |
| SCHEMBL7779480 | 0.77 | PTGS2 (0.45) | PTGS2LRRK2PTGS1 | |
| SCHEMBL7779772 | 0.74 | LRRK2 (0.50) | PTGS2LRRK2PTGS1 | |
| SCHEMBL7777288 | 0.74 | PTGS2 (0.45) | PTGS2PTGS1 | |
| SCHEMBL8179840 | 0.74 | PTGS2 (0.46) | PTGS2LRRK2 | |
| SCHEMBL7778123 | 0.73 | PTGS2 (0.44) | PTGS2LRRK2 | |
| SCHEMBL7779923 | 0.72 | PTGS2 (0.44) | PTGS2LRRK2PTGS1 | |
| SCHEMBL7778222 | 0.72 | PTGS2 (0.44) | PTGS2LRRK2PTGS1 | |
| SCHEMBL8627686 | 0.71 | PTGS2 (0.51) | PTGS2PTGS1 | |
| SCHEMBL7779618 | 0.70 | PTGS2 (0.57) | PTGS2LRRK2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |