Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 4/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8634891 | 0.93 | PTGS2 (0.73) | PTGS2PTGS1CA9CA12TRPM2 | |
| SCHEMBL8633238 | 0.92 | PTGS2 (0.84) | PTGS2PTGS1GAACA9CA12 | |
| SCHEMBL8631631 | 0.91 | PTGS2 (0.70) | PTGS2PTGS1CA9CA12TRPM2 | |
| SCHEMBL8632520 | 0.91 | PTGS2 (0.85) | PTGS2PTGS1MEN1KMT2AGAA | |
| SCHEMBL8630457 | 0.91 | PTGS2 (0.69) | PTGS2PTGS1CA9CA12TRPM2 | |
| SCHEMBL8635122 | 0.90 | PTGS2 (0.68) | PTGS2PTGS1MEN1KMT2ACA9 | |
| SCHEMBL8632389 | 0.90 | PTGS2 (0.63) | PTGS2PTGS1MEN1KMT2AGAA | |
| SCHEMBL8631062 | 0.87 | PTGS2 (0.67) | PTGS2PTGS1CA9CA12TRPM2 | |
| SCHEMBL7780571 | 0.87 | PTGS2 (0.63) | PTGS2PTGS1CA9CA1CA2 | |
| SCHEMBL8631373 | 0.86 | PTGS2 (0.63) | PTGS2PTGS1CA9CA12TRPM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |