Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.53 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 5/20 | 0.42 |
| ▸ | CA12 | O43570 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630528 | 0.92 | PTGS2 (0.75) | PTGS2PTGS1TRPM2MEN1KMT2A | |
| SCHEMBL8629917 | 0.90 | PTGS2 (0.72) | PTGS2PTGS1TRPM2MEN1KMT2A | |
| SCHEMBL7773308 | 0.89 | PTGS2 (0.54) | PTGS2PTGS1CA9CA12CA1 | |
| SCHEMBL8634891 | 0.87 | PTGS2 (0.73) | PTGS2PTGS1TRPM2CA9CA12 | |
| SCHEMBL7780842 | 0.86 | PTGS2 (0.70) | PTGS2PTGS1CA9CA12CA1 | |
| SCHEMBL8633238 | 0.86 | PTGS2 (0.84) | PTGS2PTGS1TRPM2GAACA9 | |
| SCHEMBL8631631 | 0.85 | PTGS2 (0.70) | PTGS2PTGS1TRPM2CA9CA12 | |
| SCHEMBL8631062 | 0.85 | PTGS2 (0.67) | PTGS2PTGS1TRPM2CA9CA12 | |
| SCHEMBL8630457 | 0.84 | PTGS2 (0.69) | PTGS2PTGS1TRPM2CA9CA12 | |
| SCHEMBL8634628 | 0.84 | PTGS2 (0.59) | PTGS2PTGS1TRPM2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |