Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | GYS1 | P13807 | 4/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633926 | 0.90 | MAPT (0.46) | MAPTALDH1A1LMNAGPR55CNR1 | |
| SCHEMBL8630119 | 0.89 | MAPT (0.45) | MAPTALDH1A1LMNAGPR55CNR1 | |
| SCHEMBL8630534 | 0.87 | MAPT (0.60) | MAPTALDH1A1LMNAGPR55CNR1 | |
| SCHEMBL8631356 | 0.83 | GYS1 (0.57) | MAPTALDH1A1LMNAGPR55CNR1 | |
| SCHEMBL8634944 | 0.83 | LRRK2 (0.49) | MAPTLMNAGPR55CNR1CNR2 | |
| SCHEMBL8627701 | 0.82 | GYS1 (0.46) | MAPTGPR55CNR1CNR2MEN1 | |
| SCHEMBL8634599 | 0.82 | LRRK2 (0.46) | MAPTALDH1A1LMNAGPR55CNR1 | |
| SCHEMBL7777717 | 0.82 | MAP2K7 (0.53) | GYS1ABCC8KCNJ11LRRK2 | |
| SCHEMBL8629857 | 0.80 | LRRK2 (0.48) | MAPTALDH1A1LMNAGPR55CNR1 | |
| SCHEMBL8635288 | 0.80 | MAPT (0.42) | MAPTALDH1A1LMNAGPR55CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |