Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 20/20 | 0.51 |
| ▸ | EGLN3 | Q9H6Z9 | 4/20 | 0.51 |
| ▸ | VEGFA | P15692 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.43 |
| ▸ | TET3 | O43151 | 1/20 | 0.43 |
| ▸ | ASPH | Q12797 | 1/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.43 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.43 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.43 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.43 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628694 | 0.92 | EGLN1 (0.45) | EGLN1EGLN3VEGFAFLT1BBOX1 | |
| SCHEMBL6564105 | 0.91 | EGLN1 (0.48) | EGLN1EGLN3BBOX1HIF1ANFTO | |
| SCHEMBL8627667 | 0.90 | EGLN1 (0.51) | EGLN1EGLN3VEGFAFLT1BBOX1 | |
| SCHEMBL8629275 | 0.90 | EGLN1 (0.44) | EGLN1EGLN3VEGFAFLT1BBOX1 | |
| SCHEMBL8628250 | 0.89 | EGLN1 (0.46) | EGLN1EGLN3HIF1ANFTOKDM5B | |
| SCHEMBL6567419 | 0.89 | EGLN1 (0.51) | EGLN1EGLN3HIF1ANFTOKDM5B | |
| SCHEMBL8626818 | 0.89 | EGLN1 (0.44) | EGLN1EGLN3VEGFAFLT1BBOX1 | |
| SCHEMBL8629451 | 0.87 | EGLN1 (0.55) | EGLN1EGLN3HIF1ANFTOKDM5B | |
| SCHEMBL8629874 | 0.86 | EGLN1 (0.52) | EGLN1HIF1ANFTOKDM5BKDM2A | |
| SCHEMBL8629988 | 0.86 | EGLN1 (0.48) | EGLN1HIF1ANFTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| CN-1154365-A | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | HOECHST AG (DE) | 1997-07-16 | — | — | CN | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |