Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.43 |
| ▸ | NAMPT | P43490 | 4/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.39 |
| ▸ | HIF1AN | Q9NWT6 | 2/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.38 |
| ▸ | VEGFA | P15692 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629988 | 0.89 | EGLN1 (0.48) | EGLN1FTOHIF1AN | |
| SCHEMBL8629876 | 0.86 | EGLN1 (0.51) | EGLN1NAMPTFTOHIF1ANPDE4B | |
| SCHEMBL6564105 | 0.85 | EGLN1 (0.48) | EGLN1NAMPTFTOEGLN3HIF1AN | |
| SCHEMBL8629264 | 0.83 | EGLN1 (0.51) | EGLN1FTOEGLN3HIF1ANKDM5B | |
| SCHEMBL8628250 | 0.83 | EGLN1 (0.46) | EGLN1FTOEGLN3HIF1ANKDM6B | |
| SCHEMBL8629451 | 0.83 | EGLN1 (0.55) | EGLN1FTOEGLN3HIF1ANKDM6B | |
| SCHEMBL6567419 | 0.83 | EGLN1 (0.51) | EGLN1FTOEGLN3HIF1ANKDM5B | |
| SCHEMBL8630076 | 0.83 | EGLN1 (0.45) | EGLN1EGLN3 | |
| SCHEMBL8629275 | 0.82 | EGLN1 (0.44) | EGLN1NAMPTFTOEGLN3HIF1AN | |
| SCHEMBL8628694 | 0.82 | EGLN1 (0.45) | EGLN1FTOEGLN3HIF1ANKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |