Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.37 |
| ▸ | FEN1 | P39748 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631453 | 0.90 | PTGS2 (0.47) | PTGS2PTGS1ABCB11ALDH1A1F10 | |
| SCHEMBL8629941 | 0.89 | PTGS2 (0.46) | PTGS2PTGS1ABCB11ALDH1A1NPSR1 | |
| SCHEMBL8629948 | 0.88 | PTGS2 (0.45) | PTGS2PTGS1ABCB11ALDH1A1NPSR1 | |
| SCHEMBL8635135 | 0.87 | PTGS2 (0.45) | PTGS2PTGS1ABCB11ALDH1A1F10 | |
| SCHEMBL8631727 | 0.86 | PTGS2 (0.44) | PTGS2PTGS1NPSR1F10ALOX5AP | |
| SCHEMBL8631949 | 0.86 | PTGS2 (0.46) | PTGS2PTGS1NPSR1F10ALOX5AP | |
| SCHEMBL7780861 | 0.86 | PTGS2 (0.54) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8632811 | 0.86 | PTGS2 (0.43) | PTGS2PTGS1ABCB11ALDH1A1F10 | |
| SCHEMBL8633822 | 0.84 | POLB (0.33) | PTGS2PTGS1ALDH1A1NPSR1F10 | |
| SCHEMBL8629873 | 0.83 | PTGS2 (0.41) | PTGS2PTGS1F10ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |