Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 6/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.33 |
| ▸ | FEN1 | P39748 | 4/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635408 | 0.90 | PTGS2 (0.36) | POLBPTGS1PTGS2F10ALOX5AP | |
| SCHEMBL8629841 | 0.88 | PTGS2 (0.39) | PTGS1PTGS2F10ALOX5APFEN1 | |
| SCHEMBL8630040 | 0.87 | POLB (0.36) | POLBPTGS2F10ALOX5APFEN1 | |
| SCHEMBL8628877 | 0.85 | PTGS2 (0.42) | POLBPTGS1PTGS2ALDH1A1KDM4E | |
| SCHEMBL8629079 | 0.85 | F10 (0.36) | POLBPTGS2F10CA12CA2 | |
| SCHEMBL8632205 | 0.84 | PTGS2 (0.45) | POLBPTGS1PTGS2F10ALOX5AP | |
| SCHEMBL8630167 | 0.84 | PTGS2 (0.44) | PTGS1PTGS2F10ALOX5APFEN1 | |
| SCHEMBL7780500 | 0.84 | PTGS2 (0.47) | PTGS1PTGS2CA12CA2CA9 | |
| SCHEMBL8631787 | 0.83 | PTGS2 (0.40) | POLBPTGS2F10CA2CA9 | |
| SCHEMBL8633375 | 0.83 | F10 (0.37) | POLBPTGS2F10CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |