SCHEMBL8630427

SCHEMBL8630427

CC(C)(C(=O)OC(=O)COc1ccccc1)N1CCN(c2ccncc2)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 1/20 0.47
ITGA2B P08514 1/20 0.47
HRH3 Q9Y5N1 9/20 0.46
MAPK1 P28482 2/20 0.46
HRH1 P35367 2/20 0.45
HRH2 P25021 1/20 0.45
ME2 P23368 1/20 0.45
ME1 P48163 1/20 0.45
ME3 Q16798 1/20 0.45
ATM Q13315 1/20 0.43
KDM4E B2RXH2 1/20 0.43
TSHR P16473 2/20 0.42
NPSR1 Q6W5P4 2/20 0.42
ALDH1A1 P00352 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
HIF1A Q16665 1/20 0.42
METAP1 P53582 1/20 0.42
MAPT P10636 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8634854 0.79 ITGB3 (0.51) ITGB3ITGA2BHRH3MAPK1HRH1
SCHEMBL8696504 0.79 HRH3 (0.51) ITGB3ITGA2BHRH3MAPK1HRH1
SCHEMBL8654423 0.78 ITGB3 (0.45) ITGB3ITGA2BHRH3MAPK1HRH1
SCHEMBL7394882 0.77 HRH3 (0.49) ITGB3ITGA2BHRH3HRH1ALDH1A1
SCHEMBL7400055 0.76 ITGB3 (0.54) ITGB3ITGA2BHRH3HRH1ALDH1A1
SCHEMBL8630370 0.74 KCNH2 (0.46) ITGB3ITGA2BHRH3MAPK1HRH1
SCHEMBL8630425 0.73 TSHR (0.44) ITGB3ITGA2BHRH3MAPK1HRH1
SCHEMBL8635262 0.73 ITGB3 (0.48) ITGB3ITGA2BHRH3MAPK1HRH1
SCHEMBL8634057 0.72 CYP2C9 (0.43) ITGB3ITGA2BHRH3MAPK1HRH1
SCHEMBL8635833 0.71 CYP2C9 (0.45) ITGB3ITGA2BHRH3MAPK1HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5753659-A ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, ZENECA LIMITED (GB) 1998-05-19 US disclosed
US-5750754-A TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS ZENECA LIMITED (GB) 1998-05-12 US disclosed