SCHEMBL8630455

SCHEMBL8630455

ClCc1cccc(Oc2ccnc(Cl)c2)n1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.37
MAP4K4 O95819 1/20 0.36
PPARG P37231 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
GRM5 P41594 3/20 0.35
F2 P00734 1/20 0.34
F10 P00742 1/20 0.34
RECQL P46063 1/20 0.33
LOX P28300 1/20 0.33
LOXL3 P58215 1/20 0.33
LOXL2 Q9Y4K0 1/20 0.33
GAA P10253 1/20 0.32
HTT P42858 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
KCNH2 Q12809 1/20 0.32
GPR119 Q8TDV5 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8633367 0.87 PPARG (0.43) L3MBTL1MAP4K4PPARGCYP1A2CYP2C9
SCHEMBL8627197 0.87 RECQL (0.42) L3MBTL1MAP4K4PPARGCYP1A2CYP2C9
SCHEMBL8721109 0.86 F2 (0.44) L3MBTL1MAP4K4PPARGCYP1A2CYP2C9
SCHEMBL8694570 0.80 GRM5 (0.43) L3MBTL1MAP4K4PPARGGRM5KCNH2
SCHEMBL8692569 0.80 PPARG (0.42) L3MBTL1PPARGGRM5HTTMEN1
SCHEMBL8628556 0.80 GRM5 (0.47) PPARGGRM5MEN1KMT2AKCNH2
SCHEMBL8721952 0.77 PTGER1 (0.44) PPARGCYP2C19GRM5LOXLOXL2
SCHEMBL8629313 0.77 MAPT (0.45) L3MBTL1PPARGGRM5KCNH2
SCHEMBL8627523 0.77 MAPT (0.45) L3MBTL1PPARGGRM5KCNH2
SCHEMBL28015517 0.76 MEN1 (0.46) L3MBTL1F2F10HTTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5807804-A CONTROLLING WEEDS AMERICAN CYANAMID COMPANY (US) 1998-09-15 US disclosed
US-5710106-A Substituted pyridine herbicidal agents AMERICAN CYANAMID COMPANY (US) 1998-01-20 US disclosed
EP-0792872-A2 2,6-substituted pyridine derivatives, their preparation and their use as herbicidal agents American Cyanamid Company (US) 1997-09-03 EP disclosed