Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | ASPH | Q12797 | 1/20 | 0.41 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | STAMBP | O95630 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566241 | 0.93 | CYP1A2 (0.45) | SMN1; SMN2KMT2AMEN1L3MBTL1THRB | |
| SCHEMBL8630092 | 0.91 | MAPK14 (0.45) | SMN1; SMN2KMT2AMEN1L3MBTL1EGLN1 | |
| SCHEMBL6567471 | 0.89 | KMT2A (0.48) | KMT2AMEN1L3MBTL1EGLN1HSP90AA1 | |
| SCHEMBL27464666 | 0.88 | KMT2A (0.47) | SMN1; SMN2KMT2AMEN1L3MBTL1HSP90AA1 | |
| SCHEMBL8632231 | 0.87 | KMT2A (0.56) | SMN1; SMN2KMT2AMEN1L3MBTL1GAA | |
| SCHEMBL6567159 | 0.85 | PLA2G2D (0.47) | KMT2AMEN1L3MBTL1HSP90AA1MAPT | |
| SCHEMBL6565058 | 0.85 | KMT2A (0.47) | KMT2AMEN1L3MBTL1HSP90AA1ALDH1A1 | |
| SCHEMBL8625913 | 0.85 | KMT2A (0.48) | SMN1; SMN2KMT2AMEN1L3MBTL1HSP90AA1 | |
| SCHEMBL8629721 | 0.85 | KMT2A (0.48) | KMT2AMEN1L3MBTL1GAAGLA | |
| SCHEMBL8631264 | 0.85 | KMT2A (0.44) | SMN1; SMN2KMT2AMEN1L3MBTL1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1120157-C | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | FIBER GENE CORP (US) | 2003-09-03 | — | — | CN | disclosed |
| CN-1282737-A | Intermediate product used for preparing substituted quinoline-2-formamide | MOECHST AG (DE) | 2001-02-07 | — | — | CN | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| CN-1154365-A | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | HOECHST AG (DE) | 1997-07-16 | — | — | CN | disclosed |