Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630512 | 0.95 | MTNR1A (0.44) | KMT2AMEN1HSP90AA1PLA2G2DL3MBTL1 | |
| SCHEMBL6567159 | 0.95 | PLA2G2D (0.47) | KMT2AMEN1HSP90AA1PLA2G2DL3MBTL1 | |
| SCHEMBL27464666 | 0.94 | KMT2A (0.47) | KMT2AMEN1HSP90AA1L3MBTL1EGFR | |
| SCHEMBL6565681 | 0.92 | L3MBTL1 (0.44) | KMT2AMEN1HSP90AA1L3MBTL1NPC1 | |
| SCHEMBL6565058 | 0.91 | KMT2A (0.47) | KMT2AMEN1HSP90AA1L3MBTL1POLB | |
| SCHEMBL6567471 | 0.85 | KMT2A (0.48) | KMT2AMEN1HSP90AA1L3MBTL1POLB | |
| SCHEMBL8629309 | 0.85 | MEN1 (0.53) | KMT2AMEN1HSP90AA1PLA2G2DPPARG | |
| SCHEMBL8630494 | 0.85 | SMN1; SMN2 (0.51) | KMT2AMEN1HSP90AA1L3MBTL1MAPT | |
| SCHEMBL8629057 | 0.84 | MEN1 (0.52) | KMT2AMEN1HSP90AA1PLA2G2DPPARG | |
| SCHEMBL8630299 | 0.82 | PLA2G2D (0.50) | KMT2AMEN1HSP90AA1PLA2G2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1120157-C | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | FIBER GENE CORP (US) | 2003-09-03 | — | — | CN | disclosed |
| CN-1282737-A | Intermediate product used for preparing substituted quinoline-2-formamide | MOECHST AG (DE) | 2001-02-07 | — | — | CN | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| CN-1154365-A | Substituted quinoline-2-carboxamides, process for their preparation and their use as pharmaceuticals, and intermediates thereof | HOECHST AG (DE) | 1997-07-16 | — | — | CN | disclosed |