Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630494 | 0.89 | SMN1; SMN2 (0.51) | KMT2AMEN1L3MBTL1HSP90AA1GAA | |
| SCHEMBL27464666 | 0.88 | KMT2A (0.47) | KMT2AMEN1L3MBTL1HSP90AA1MAPT | |
| SCHEMBL6567159 | 0.85 | PLA2G2D (0.47) | KMT2AMEN1L3MBTL1HSP90AA1MAPT | |
| SCHEMBL6565058 | 0.85 | KMT2A (0.47) | KMT2AMEN1L3MBTL1HSP90AA1MAPT | |
| SCHEMBL6566241 | 0.85 | CYP1A2 (0.45) | KMT2AMEN1L3MBTL1MAPT | |
| SCHEMBL8625913 | 0.85 | KMT2A (0.48) | KMT2AMEN1L3MBTL1HSP90AA1MAPT | |
| SCHEMBL8632231 | 0.85 | KMT2A (0.56) | KMT2AMEN1L3MBTL1GAAMAPT | |
| SCHEMBL8631264 | 0.85 | KMT2A (0.44) | KMT2AMEN1L3MBTL1HSP90AA1GAA | |
| SCHEMBL8629707 | 0.84 | MCL1 (0.51) | KMT2AMEN1L3MBTL1HSP90AA1MCL1 | |
| SCHEMBL8629721 | 0.83 | KMT2A (0.48) | KMT2AMEN1L3MBTL1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |