Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.43 |
| ▸ | GYS1 | P13807 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629857 | 0.91 | LRRK2 (0.48) | LRRK2GYS1MAPTCNR1CNR2 | |
| SCHEMBL8631595 | 0.90 | GYS1 (0.48) | LRRK2GYS1MAPTCNR1CNR2 | |
| SCHEMBL8628165 | 0.89 | LRRK2 (0.43) | LRRK2GYS1MAPTCNR1CNR2 | |
| SCHEMBL8632688 | 0.82 | GYS1 (0.58) | LRRK2GYS1MAPTCNR1CNR2 | |
| SCHEMBL7773229 | 0.81 | LRRK2 (0.50) | LRRK2CA12CA2CA9 | |
| SCHEMBL8629979 | 0.81 | GYS1 (0.58) | LRRK2GYS1MAPTCNR1CNR2 | |
| SCHEMBL8631356 | 0.81 | GYS1 (0.57) | LRRK2GYS1MAPTCNR1CNR2 | |
| SCHEMBL8635394 | 0.81 | LRRK2 (0.49) | LRRK2GYS1MAPTCNR1CNR2 | |
| SCHEMBL8635017 | 0.80 | GYS1 (0.47) | LRRK2GYS1MAPTCNR1CNR2 | |
| SCHEMBL8633593 | 0.80 | MAPT (0.51) | LRRK2GYS1MAPTCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |