SCHEMBL8630623

SCHEMBL8630623

COC1CCC(CC(=O)N2CCC(NC(C)=O)CC2)c2cc(F)ccc2N1C(=O)c1ccc(NC(=O)c2ccccc2Br)cc1

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.40
USP2 O75604 1/20 0.37
ALDH1A1 P00352 1/20 0.37
TP53 P04637 1/20 0.37
HPGD P15428 1/20 0.37
MAPK1 P28482 1/20 0.37
POLB P06746 1/20 0.37
NPC1 O15118 1/20 0.36
NPY2R P49146 1/20 0.36
EPHX2 P34913 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8631919 0.92 NPY2R (0.39) KMT2AUSP2ALDH1A1TP53HPGD
SCHEMBL8630121 0.85 NPY2R (0.38) KMT2AALDH1A1HPGDNPC1NPY2R
SCHEMBL8629514 0.84 AVPR2 (0.44)
SCHEMBL8630620 0.83 AVPR1A (0.44) KMT2A
SCHEMBL4685814 0.80 KMT2A (0.42) KMT2AUSP2ALDH1A1TP53HPGD
SCHEMBL7353320 0.78 AVPR2 (0.55)
SCHEMBL8630141 0.78 AVPR2 (0.42) KMT2A
SCHEMBL8630871 0.76 AVPR2 (0.44)
Hydrochloric Acid SCHEMBL8634086 0.75 AVPR2 (0.43)
SCHEMBL8627338 0.75 AVPR2 (0.47)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5753644-A Vasopressin antagonist and oxytocin antagonist OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1998-05-19 US disclosed