Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10904425 | 0.84 | KDM4E (0.50) | KDM4ENPC1MAPTHTTJAK2 | |
| SCHEMBL15518189 | 0.83 | ALDH1A1 (0.58) | NPC1MAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2904007 | 0.83 | NOTUM (0.61) | MAPTHTTNOTUMSMN1; SMN2ALDH1A1 | |
| SCHEMBL5162627 | 0.82 | ALDH1A1 (0.68) | KDM4EMAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8633156 | 0.80 | KDM4E (0.47) | KDM4ENPC1MAPTHTTJAK2 | |
| SCHEMBL10506317 | 0.79 | SMN1; SMN2 (0.60) | KDM4EMAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10428803 | 0.78 | KMT2A (0.57) | NPC1MAPTNOTUMSMN1; SMN2ALDH1A1 | |
| SCHEMBL10898603 | 0.77 | IDO1 (0.54) | KDM4ENPC1MAPTHTTSMN1; SMN2 | |
| SCHEMBL10900892 | 0.77 | CASP3 (0.47) | KDM4ENPC1MAPTHTTJAK2 | |
| SCHEMBL8202795 | 0.77 | KDM4E (0.47) | KDM4ENPC1MAPTHTTJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753659-A | ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, | ZENECA LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| US-5750754-A | TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS | ZENECA LIMITED (GB) | 1998-05-12 | — | — | US | disclosed |
| US-5563141-A | INHIBIT CELL ADHESION FOR EXAMPLE, PLATELET AGGRE GATION | ZENECA LIMITED (GB) | 1996-10-08 | — | — | US | disclosed |