Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.67 |
| ▸ | NPC1 | O15118 | 9/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.64 |
| ▸ | LMNA | P02545 | 6/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.60 |
| ▸ | RELA | Q04206 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | GALR3 | O60755 | 1/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31325523 | 0.84 | RAB9A (0.77) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL12604486 | 0.84 | RAB9A (0.77) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL13742575 | 0.83 | CYP1A2 (0.70) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL9692985 | 0.83 | RAB9A (0.60) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL8600005 | 0.81 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL12604482 | 0.81 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL2949736 | 0.81 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL31325504 | 0.81 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL8659490 | 0.80 | OPRL1 (0.49) | RAB9ANPC1SMN1; SMN2LMNAHTT | |
| SCHEMBL12604481 | 0.78 | RAB9A (0.77) | RAB9ANPC1SMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0830346-A1 | 2-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-25 | — | — | EP | claimed |
| US-5684030-A | HYPOTENSIVE AGENTS, ANTIPROLIFERATION AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-11-04 | — | — | US | claimed |
| WO-1996040645-A1 | 2-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-19 | — | — | WO | claimed |
| EP-0830346-A1 | 2-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-25 | — | — | EP | disclosed |
| US-5684030-A | HYPOTENSIVE AGENTS, ANTIPROLIFERATION AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |
| WO-1996040645-A1 | 2-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-19 | — | — | WO | disclosed |