Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 9/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | TXN | P10599 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211295 | 0.82 | ALOX5 (0.67) | OPRL1SMN1; SMN2PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL12963079 | 0.81 | OPRL1 (0.60) | OPRL1RAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL8631022 | 0.80 | RAB9A (0.67) | RAB9ASMN1; SMN2NPC1LMNAHTT | |
| SCHEMBL8291911 | 0.78 | SMN1; SMN2 (0.46) | OPRL1RAB9ASMN1; SMN2PRKAG1PRKAA2 | |
| SCHEMBL8291917 | 0.77 | ALOX5 (0.64) | OPRL1SMN1; SMN2PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL9692985 | 0.77 | RAB9A (0.60) | DAORAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL4207157 | 0.76 | RAB9A (0.58) | RAB9ASMN1; SMN2PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL12963220 | 0.76 | CYP1A2 (0.52) | OPRL1TXNRAB9ASMN1; SMN2PRKAG1 | |
| SCHEMBL8634298 | 0.75 | MAPT (0.61) | DAORAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL12932936 | 0.75 | CYP1A2 (0.53) | OPRL1TXNSMN1; SMN2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0830346-A1 | 2-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-25 | — | — | EP | claimed |
| US-5684030-A | HYPOTENSIVE AGENTS, ANTIPROLIFERATION AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-11-04 | — | — | US | claimed |
| WO-1996040645-A1 | 2-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-19 | — | — | WO | claimed |
| EP-0830346-A1 | 2-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-25 | — | — | EP | disclosed |
| US-5684030-A | HYPOTENSIVE AGENTS, ANTIPROLIFERATION AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |
| WO-1996040645-A1 | 2-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS INHIBITORS OF SMOOTH MUSCLE CELL PROLIFERATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-19 | — | — | WO | disclosed |