Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24675593 | 1.00 | GAA (0.59) | GAANPSR1PTPN1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL29823025 | 0.98 | GAA (0.57) | GAANPSR1PTPN1KDM4EALDH1A1 | |
| SCHEMBL2624372 | 0.87 | GAA (0.62) | GAANPSR1PTPN1KDM4EALDH1A1 | |
| SCHEMBL6577434 | 0.84 | GAA (0.59) | GAANPSR1PTPN1KDM4EALDH1A1 | |
| SCHEMBL10282672 | 0.84 | ALDH1A1 (0.69) | GAANPSR1PTPN1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9396026 | 0.84 | GAA (0.52) | GAANPSR1PTPN1KDM4EALDH1A1 | |
| SCHEMBL8623784 | 0.83 | GAA (0.57) | GAANPSR1PTPN1KDM4EALDH1A1 | |
| SCHEMBL12742268 | 0.83 | GAA (0.57) | GAANPSR1PTPN1KDM4EALDH1A1 | |
| SCHEMBL9772783 | 0.82 | GAA (0.56) | GAANPSR1PTPN1KDM4EALDH1A1 | |
| SCHEMBL11815554 | 0.81 | GAA (0.72) | GAANPSR1PTPN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A9 | DEGRADERS OF GRK2 AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |
| WO-1998009625-A1 | SELECTIVE β3 ADRENERGIC AGONISTS | ELI LILLY AND COMPANY (US) | 1998-03-12 | — | — | WO | disclosed |