Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.37 |
| ▸ | F10 | P00742 | 10/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8627803 | 0.93 | PTGS2 (0.37) | PTGS2PTGS1F10TRPV1F2 | |
| SCHEMBL8629866 | 0.92 | F10 (0.36) | PTGS2PTGS1F10TRPV1PDPK1 | |
| SCHEMBL8631554 | 0.92 | PTGS2 (0.46) | PTGS2PTGS1F10TRPV1F2 | |
| SCHEMBL8629763 | 0.91 | F10 (0.39) | PTGS2PTGS1F10TRPV1PDPK1 | |
| SCHEMBL8635118 | 0.89 | F10 (0.46) | PTGS2PTGS1F10F2 | |
| SCHEMBL8634395 | 0.89 | PTGS2 (0.38) | PTGS2PTGS1F10TRPV1F2 | |
| SCHEMBL8631100 | 0.88 | PTGS2 (0.39) | PTGS2PTGS1F10TRPV1CA12 | |
| SCHEMBL8628757 | 0.88 | F10 (0.38) | PTGS2PTGS1F10TRPV1F2 | |
| SCHEMBL8634436 | 0.86 | F10 (0.40) | F10CA12CA2CA9 | |
| SCHEMBL8628007 | 0.84 | PTGS2 (0.40) | PTGS2PTGS1F10PDPK1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |