Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630545 | 0.92 | AR (0.38) | PTGS2SMN1; SMN2ARTDP1PTGS1 | |
| SCHEMBL8630521 | 0.91 | PTGS1 (0.45) | PTGS2SMN1; SMN2ARENPP1PTGS1 | |
| SCHEMBL8632230 | 0.91 | PTGS2 (0.37) | PTGS2SMN1; SMN2ARPTGS1CYP3A4 | |
| SCHEMBL8635633 | 0.89 | AR (0.36) | PTGS2ARPTGS1KDM4EF10 | |
| SCHEMBL8634661 | 0.87 | PTGS2 (0.45) | PTGS2SMN1; SMN2TDP1ENPP1PTGS1 | |
| SCHEMBL7779927 | 0.86 | PTGS2 (0.48) | PTGS2SMN1; SMN2ARTDP1ENPP1 | |
| SCHEMBL8635053 | 0.86 | PTGS1 (0.44) | PTGS2SMN1; SMN2ARPTGS1CYP1A2 | |
| SCHEMBL8635575 | 0.86 | PTGS2 (0.46) | PTGS2SMN1; SMN2TDP1ENPP1PTGS1 | |
| SCHEMBL8633055 | 0.84 | AR (0.39) | PTGS2ARPTGS1F10F2 | |
| SCHEMBL8632163 | 0.84 | PTGS2 (0.43) | PTGS2PTGS1TP53F10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |