Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | F10 | P00742 | 7/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628841 | 0.92 | PTGS2 (0.43) | PTGS2PTGS1F10F2ALOX5AP | |
| SCHEMBL8630861 | 0.91 | PTGS2 (0.53) | PTGS2PTGS1F10F2ALOX5AP | |
| SCHEMBL8631579 | 0.90 | PTGS2 (0.42) | PTGS2PTGS1F10PDPK1CYP3A4 | |
| SCHEMBL8631395 | 0.90 | F10 (0.47) | PTGS2PTGS1F10F2 | |
| SCHEMBL8629107 | 0.90 | PTGS2 (0.43) | PTGS2PTGS1F10F2ALOX5AP | |
| SCHEMBL8629412 | 0.88 | PTGS2 (0.38) | PTGS2PTGS1F10CA12CA2 | |
| SCHEMBL8632378 | 0.88 | PTGS2 (0.41) | PTGS2PTGS1F10F2ALOX5AP | |
| SCHEMBL8630025 | 0.88 | PTGS2 (0.58) | PTGS2PTGS1F10PDPK1CA12 | |
| SCHEMBL8630040 | 0.87 | POLB (0.36) | PTGS2F10CA12CA2CA9 | |
| SCHEMBL8629933 | 0.85 | PTGS2 (0.46) | PTGS2PTGS1F10CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |