Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 7/20 | 0.42 |
| ▸ | LPAR3 | Q9UBY5 | 6/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.40 |
| ▸ | LAP3 | P28838 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355129 | 0.87 | KDM4E (0.44) | FDPSLAP3KDM4EMMP2THRB | |
| SCHEMBL264477 | 0.83 | — | — | |
| Butane SCHEMBL14675942 | 0.82 | FDPS (0.42) | FDPSLPAR3LPAR2LAP3LPAR1 | |
| SCHEMBL1573316 | 0.82 | — | — | |
| SCHEMBL28969669 | 0.80 | — | — | |
| SCHEMBL9261417 | 0.79 | HPGD (0.59) | FDPSLPAR3LPAR2LPAR1 | |
| SCHEMBL13695320 | 0.76 | PPARD (0.33) | FDPSLPAR3LPAR2LAP3KDM4E | |
| SCHEMBL264330 | 0.76 | ALDH1A1 (0.44) | LPAR3LPAR2LPAR1THRB | |
| SCHEMBL5844279 | 0.76 | LPAR3 (0.57) | FDPSLPAR3LPAR2LPAR1THRB | |
| SCHEMBL11298274 | 0.76 | TSHR (0.57) | FDPSLPAR3LPAR2LPAR1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726311-A | IMMUNOSUPPRESSANTS | BIOCRYST PHARMACEUTICALS, INC. (US) | 1998-03-10 | — | — | US | disclosed |
| EP-0638080-A4 | 7-DISUBSTITUTED-METHYL-4-OXO-3H -,5H --PYRROLO 3,2-d -]PYRIMIDINE AND PHARMACEUTICAL USES AND COMPOSITIONS CONTAINING THE SAME. | BIOCRYST PHARM INC (US) | 1995-08-23 | — | — | EP | disclosed |
| EP-0500653-A4 | INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE | BIOCRYST INC (US) | 1995-08-23 | — | — | EP | disclosed |
| EP-0638080-A1 | 7-DISUBSTITUTED-METHYL-4-OXO-3H -,5H --PYRROLO 3,2-d -]PYRIMIDINE AND PHARMACEUTICAL USES AND COMPOSITIONS CONTAINING THE SAME | BIOCRYST PHARMACEUTICALS, INC. (US) | 1995-02-15 | — | — | EP | disclosed |
| WO-1993021187-A1 | 7-DISUBSTITUTED-METHYL-4-OXO-3H^_,5H^_-PYRROLO[3,2-d^_]PYRIMIDINE AND PHARMACEUTICAL USES AND COMPOSITIONS CONTAINING THE SAME | BIOCRYST PHARMACEUTICALS, INC. (US) | 1993-10-28 | — | — | WO | disclosed |
| US-5189039-A | 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo[3,2d]pyrimidine and pharmaceutical uses and compositions containing the same | BIOCRYST, INC. (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0500653-A1 | INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE | BIOCRYST PHARMACEUTICALS INC. (US) | 1992-09-02 | — | — | EP | disclosed |
| WO-1991006548-A1 | INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE | BIOCRYST, INC. (US) | 1991-05-16 | — | — | WO | disclosed |