SCHEMBL8632256

SCHEMBL8632256

N#Cc1ccc(Oc2cccc(F)c2Oc2ccc(C#N)c(C#N)c2)cc1C#N

nearest known ligand 0.61

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
AR P10275 15/20 0.61
CYP19A1 P11511 1/20 0.46
SLC22A12 Q96S37 1/20 0.41
MAOB P27338 1/20 0.41
ALDH1A1 P00352 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27994023 0.86 AR (0.51) ARCYP19A1SLC22A12MAOBALDH1A1
SCHEMBL23795081 0.84 AR (0.51) ARCYP19A1MAOBALDH1A1SMN1; SMN2
SCHEMBL9747084 0.83 ALDH1A1 (0.51) ARCYP19A1MAOBALDH1A1SMN1; SMN2
SCHEMBL23795083 0.83 AR (0.48) ARCYP19A1SLC22A12ALDH1A1
SCHEMBL9746262 0.83 ALDH1A1 (0.51) ARCYP19A1MAOBALDH1A1SMN1; SMN2
SCHEMBL8630217 0.82 AR (0.58) ARCYP19A1
SCHEMBL1940627 0.80 AR (0.57) ARCYP19A1MAOBALDH1A1
SCHEMBL8434368 0.80 AR (0.48) ARCYP19A1MAOB
SCHEMBL23795085 0.79 AR (0.56) ARCYP19A1SLC22A12MAOBALDH1A1
SCHEMBL9746795 0.79 AR (0.53) ARCYP19A1SLC22A12MAOBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0757702-B1 POLY (IMIDE-ETHERS) DU PONT (US) 1998-07-01 EP disclosed
US-5675020-A CHEMICAL INTERMEDIATES FOR PREPARING AROMATIC POLYIMIDES THE UNIVERSITY OF LIVERPOOL (GB) 1997-10-07 US disclosed
US-5434240-A Films. fibers, encapsulation, thermoplastics THE UNIVERSITY OF LIVERPOOL (GB) 1995-07-18 US disclosed