SCHEMBL8632322

SCHEMBL8632322

C[Si](C)(C)c1cc(C(=O)O)co1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.39
HPGD P15428 2/20 0.39
TPMT P51580 2/20 0.38
TSHR P16473 2/20 0.37
ALOX15 P16050 1/20 0.37
HIF1A Q16665 1/20 0.37
HCAR2 Q8TDS4 2/20 0.36
TP53 P04637 2/20 0.35
CA12 O43570 2/20 0.34
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
CA7 P43166 2/20 0.34
CA9 Q16790 2/20 0.34
CA14 Q9ULX7 2/20 0.34
NOTUM Q6P988 1/20 0.34
DAO P14920 1/20 0.34
KEAP1 Q14145 1/20 0.34
KDM5A P29375 1/20 0.34
KDM4C Q9H3R0 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8709276 0.89 NR4A2 (0.37) NR4A2L3MBTL1HPGDTPMTTSHR
SCHEMBL4729951 0.73
SCHEMBL7956876 0.72 NR4A2 (0.42) NR4A2L3MBTL1TPMTTSHRALOX15
SCHEMBL8709279 0.72
Hydrochloric Acid SCHEMBL11786036 0.71 L3MBTL1 (0.60) NR4A2L3MBTL1TPMTTSHRHCAR2
SCHEMBL19992920 0.70
SCHEMBL5151230 0.70
SCHEMBL26907933 0.70 NR4A2 (0.43) NR4A2L3MBTL1HPGDTPMTTSHR
SCHEMBL69933 0.70 NR4A2 (0.43) NR4A2L3MBTL1HPGDTPMTTSHR
SCHEMBL6234778 0.70 NR4A2 (0.43) NR4A2L3MBTL1HPGDTPMTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5840917-A ADMINISTERING TO MAMMAL TO ERADICATE HELICOBACTER PYLORI TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-11-24 US disclosed
EP-0852498-A1 PHOSPHORYLAMIDES, THEIR PREPARATION AND USE Takeda Chemical Industries, Ltd. (JP) 1998-07-15 EP disclosed
WO-1997011705-A1 PHOSPHORYLAMIDES, THEIR PREPARATION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-04-03 WO disclosed