Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632289 | 0.89 | AKR1B1 (0.40) | LRRK2F10CA2CA9CA12 | |
| SCHEMBL8632961 | 0.88 | F10 (0.40) | LRRK2F10CA2CA9CA12 | |
| SCHEMBL8628206 | 0.87 | PTGES2 (0.39) | LRRK2CA2CA9CA12CA1 | |
| SCHEMBL8632216 | 0.87 | SCN9A (0.46) | F10 | |
| SCHEMBL8631181 | 0.86 | PTGS2 (0.50) | CA9PTGS1PTGS2 | |
| SCHEMBL8634768 | 0.86 | F10 (0.42) | LRRK2F10CA2CA9CA12 | |
| SCHEMBL8627977 | 0.86 | PTGS2 (0.50) | LRRK2F10CA2CA9CA12 | |
| SCHEMBL8630031 | 0.86 | PTGS2 (0.41) | LRRK2F10CA2CA9CA12 | |
| SCHEMBL8631346 | 0.86 | NPC1 (0.40) | LRRK2CA2CA1 | |
| SCHEMBL8630958 | 0.85 | LRRK2 (0.48) | LRRK2CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |