Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 7/20 | 0.42 |
| ▸ | KLK1 | P06870 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.39 |
| ▸ | FEN1 | P39748 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632289 | 0.89 | AKR1B1 (0.40) | F10CA2CA1CA4CA6 | |
| SCHEMBL8632961 | 0.88 | F10 (0.40) | F10CA2CA1CA4CA6 | |
| SCHEMBL8627977 | 0.86 | PTGS2 (0.50) | F10CA2CA1CA12CA9 | |
| SCHEMBL8632840 | 0.86 | LRRK2 (0.42) | F10CA2CA1CA12CA9 | |
| SCHEMBL8631181 | 0.86 | PTGS2 (0.50) | ALOX5APFEN1CA9 | |
| SCHEMBL8630958 | 0.85 | LRRK2 (0.48) | CA2CA1LRRK2 | |
| SCHEMBL8628206 | 0.84 | PTGES2 (0.39) | CA2CA1ALOX5APFEN1CA12 | |
| SCHEMBL8632216 | 0.84 | SCN9A (0.46) | F10 | |
| SCHEMBL7779730 | 0.82 | CA2 (0.57) | CA2CA1CA4CA12CA9 | |
| SCHEMBL8631406 | 0.81 | TRPV1 (0.50) | F10CA2CA1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |