Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629408 | 0.90 | MAPT (0.41) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8630200 | 0.88 | MAPT (0.50) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8631537 | 0.86 | EDNRB (0.41) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8630980 | 0.86 | KMT2A (0.39) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8632871 | 0.86 | MAPT (0.42) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8631097 | 0.84 | PTGS2 (0.43) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8632158 | 0.84 | MAPT (0.38) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8629100 | 0.83 | MAPT (0.40) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8631755 | 0.83 | MAPT (0.42) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8628674 | 0.83 | PTGS2 (0.44) | MAPTMEN1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |