Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632871 | 0.89 | MAPT (0.42) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8629408 | 0.88 | MAPT (0.41) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8633150 | 0.88 | MAPT (0.41) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8631097 | 0.88 | PTGS2 (0.43) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8629100 | 0.87 | MAPT (0.40) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8631755 | 0.87 | MAPT (0.42) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8632875 | 0.86 | SMN1; SMN2 (0.50) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8632849 | 0.85 | MAPT (0.39) | MAPTMEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL8630021 | 0.85 | SMN1; SMN2 (0.49) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8488735 | 0.83 | SMN1; SMN2 (0.46) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |