Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5173202 | 0.86 | PREP (0.51) | PREPGAAALDH1A1 | |
| SCHEMBL7284818 | 0.86 | PREP (0.51) | PREPGAAALDH1A1 | |
| SCHEMBL11447174 | 0.86 | PREP (0.51) | PREPGAAALDH1A1 | |
| SCHEMBL8637218 | 0.82 | PREP (0.50) | PREPGAAHCRTR1HCRTR2 | |
| SCHEMBL8633642 | 0.81 | HCRTR1 (0.53) | GAASMN1; SMN2FFAR1HCRTR1HCRTR2 | |
| SCHEMBL8633638 | 0.81 | HCRTR1 (0.53) | GAASMN1; SMN2FFAR1HCRTR1HCRTR2 | |
| SCHEMBL8636082 | 0.79 | TSHR (0.54) | PREPGAAHCRTR1NPSR1ALDH1A1 | |
| SCHEMBL8632678 | 0.79 | TSHR (0.54) | PREPGAAHCRTR1NPSR1ALDH1A1 | |
| SCHEMBL8635557 | 0.79 | PREP (0.69) | PREPGAAALDH1A1 | |
| SCHEMBL20059752 | 0.78 | PREP (0.41) | PREPFFAR1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0536163-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |