Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 6/20 | 0.53 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.53 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633638 | 1.00 | HCRTR1 (0.53) | HCRTR1HCRTR2SPHK2LMNAMEN1 | |
| SCHEMBL4931440 | 0.86 | SPHK2 (0.64) | HCRTR1HCRTR2SPHK2MEN1KMT2A | |
| SCHEMBL11447207 | 0.86 | SPHK2 (0.64) | HCRTR1HCRTR2SPHK2MEN1KMT2A | |
| SCHEMBL20040339 | 0.82 | HCRTR1 (0.67) | HCRTR1HCRTR2SPHK2LMNAMEN1 | |
| SCHEMBL17600741 | 0.81 | SPHK2 (0.59) | HCRTR1HCRTR2SPHK2LMNAMEN1 | |
| SCHEMBL17600738 | 0.81 | SPHK2 (0.59) | HCRTR1HCRTR2SPHK2LMNAMEN1 | |
| SCHEMBL8633260 | 0.81 | PREP (0.54) | HCRTR1HCRTR2GAASMN1; SMN2FFAR1 | |
| SCHEMBL4480837 | 0.81 | TP53 (0.60) | HCRTR1HCRTR2SPHK2LMNAMEN1 | |
| SCHEMBL4480840 | 0.81 | TP53 (0.60) | HCRTR1HCRTR2SPHK2LMNAMEN1 | |
| SCHEMBL8632697 | 0.79 | LMNA (0.57) | HCRTR1HCRTR2SPHK2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |