Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8636646 | 0.83 | PREP (0.69) | PREPKMT2AAPEX1HRH3LMNA | |
| SCHEMBL8636651 | 0.83 | PREP (0.69) | PREPKMT2AAPEX1HRH3LMNA | |
| SCHEMBL8637779 | 0.80 | PREP (0.53) | PREPKMT2AAPEX1LMNAGAA | |
| SCHEMBL8635668 | 0.80 | PREP (0.64) | PREPKMT2AAPEX1HRH3CYP3A4 | |
| SCHEMBL9538915 | 0.80 | PREP (0.64) | PREPKMT2AAPEX1HRH3CYP3A4 | |
| SCHEMBL8633260 | 0.79 | PREP (0.54) | PREPGAAALDH1A1 | |
| SCHEMBL7266943 | 0.77 | DPP4 (0.56) | KMT2AHRH3LMNAGAAALDH1A1 | |
| SCHEMBL8633510 | 0.75 | F2 (0.53) | HRH3HPGDCYP3A4CYP2C9PKM | |
| SCHEMBL7275001 | 0.75 | GAA (0.56) | PREPKMT2AHRH3LMNAGAA | |
| SCHEMBL7272291 | 0.75 | MEN1 (0.55) | KMT2AHRH3LMNAGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |