Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631183 | 0.92 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL8632515 | 0.92 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL8634887 | 0.91 | PTGS2 (0.54) | PTGS2CYP2C9PTGS1 | |
| SCHEMBL8632596 | 0.91 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL8632648 | 0.90 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL8632893 | 0.89 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL8629362 | 0.89 | PTGS2 (0.55) | PTGS2CYP2C9PTGS1 | |
| SCHEMBL8633303 | 0.88 | PTGS2 (0.54) | PTGS2CYP2C9PTGS1 | |
| SCHEMBL8630523 | 0.87 | PTGS2 (0.50) | PTGS2PTGS1ALDH1A1 | |
| SCHEMBL8630947 | 0.86 | PTGS2 (0.50) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |