Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20855518 | 0.87 | ALDH1A1 (0.54) | TDP1TSHRALDH1A1CYP3A4RECQL | |
| SCHEMBL2767547 | 0.82 | TSHR (0.60) | TDP1TSHRALDH1A1CYP3A4RECQL | |
| SCHEMBL2765848 | 0.82 | TSHR (0.60) | TDP1TSHRALDH1A1CYP3A4RECQL | |
| SCHEMBL30797376 | 0.81 | TSHR (0.56) | TSHRALDH1A1CYP3A4MAPK1HSD17B10 | |
| Bromide SCHEMBL12983645 | 0.81 | TSHR (0.58) | TDP1TSHRALDH1A1CYP3A4RECQL | |
| Bromide SCHEMBL27940668 | 0.81 | TSHR (0.58) | TDP1TSHRALDH1A1CYP3A4RECQL | |
| SCHEMBL17846885 | 0.80 | TDP1 (0.46) | TDP1TSHRALDH1A1CYP3A4RECQL | |
| SCHEMBL7737640 | 0.80 | TDP1 (0.53) | TDP1ALDH1A1MAPK1L3MBTL1MAPT | |
| SCHEMBL863252 | 0.80 | TSHR (0.53) | TDP1TSHRALDH1A1MAPK1MAPT | |
| SCHEMBL18498675 | 0.80 | ACHE (0.39) | TSHRALDH1A1CYP3A4MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621888-B1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | NOXELL CORP (US) | 2018-09-12 | — | — | EP | disclosed |
| US-20170158608-A1 | Process for the Preparation of 2-Alkoxymethyl-1,4-Benzenediamines | THE PROCTER & GAMBLE COMPANY | 2017-06-08 | — | — | US | disclosed |
| US-20170158608-A1 | Process for the Preparation of 2-Alkoxymethyl-1,4-Benzenediamines | THE PROCTER & GAMBLE COMPANY | 2017-06-08 | — | — | US | disclosed |
| WO-2017095677-A1 | PROCESS FOR THE PREPARATION OF 2-ALKOXYMETHYL-1, 4-BENZENEDIAMINES | THE PROCTER & GAMBLE COMPANY (US) | 2017-06-08 | — | — | WO | disclosed |
| US-9216945-B2 | Methods of synthesizing 2-substituted-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216945-B2 | Methods of synthesizing 2-substituted-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216945-B2 | Methods of synthesizing 2-substituted-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2015-12-22 | — | — | US | disclosed |
| US-20140081049-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | THE PROCTOR & GAMBLE COMPANY (US) | 2014-03-20 | — | — | US | disclosed |
| US-20140081049-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | THE PROCTOR & GAMBLE COMPANY (US) | 2014-03-20 | — | — | US | disclosed |
| US-20140081049-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | THE PROCTOR & GAMBLE COMPANY (US) | 2014-03-20 | — | — | US | disclosed |
| US-8618326-B2 | Methods of synthesizing 2-substituted-1,4-benzenediamine | THE PROCTER & GAMBLE COMPANY (US) | 2013-12-31 | — | — | US | disclosed |
| EP-2621888-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | The Procter and Gamble Company (US) | 2013-08-07 | — | — | EP | disclosed |
| CN-103124718-A | Method for synthesizing 2-substituted-1, 4-diphenylamine | PROCTER & GAMBLE | 2013-05-29 | — | — | CN | disclosed |
| WO-2012050593-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | THE PROCTER & GAMBLE COMPANY (US) | 2012-04-19 | — | — | WO | disclosed |
| US-20120078016-A1 | Methods of Synthesizing 2-Substituted-1,4-Benzenediamine | WELLA OPERATIONS US, LLC | 2012-03-29 | — | — | US | disclosed |
| US-20120078016-A1 | Methods of Synthesizing 2-Substituted-1,4-Benzenediamine | WELLA OPERATIONS US, LLC | 2012-03-29 | — | — | US | disclosed |
| US-20120078016-A1 | Methods of Synthesizing 2-Substituted-1,4-Benzenediamine | WELLA OPERATIONS US, LLC | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170158608-A1 | Process for the Preparation of 2-Alkoxymethyl-1,4-Benzenediamines | CYP1A1, CYP4B1, CYP1B1 | TDP1 2162/4885TSHR 1588/4885ALDH1A1 90/4885 |
| US-20120078016-A1 | Methods of Synthesizing 2-Substituted-1,4-Benzenediamine | TYR, BTD, BRD4 | TDP1 1055/4885TSHR 3127/4885ALDH1A1 837/4885 |
| US-20140081049-A1 | METHODS OF SYNTHESIZING 2- SUBSTITUTED-1,4-BENZENEDIAMINE | TYR, BTD, BRD4 | TDP1 1055/4885TSHR 3127/4885ALDH1A1 837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.