Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 18/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.66 |
| ▸ | PDE4A | P27815 | 4/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.66 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629195 | 0.96 | PDE4D (0.66) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL12596060 | 0.81 | PDE4A (0.53) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL13070911 | 0.81 | PDE4A (0.47) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL10779323 | 0.80 | PDE4A (1.00) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL8635918 | 0.80 | PDE4D (0.69) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL8633365 | 0.79 | PDE4D (0.67) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL8635605 | 0.79 | PDE4B (0.67) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| Zardaverine SCHEMBL13334 | 0.77 | PDE4A (1.00) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| Zardaverine SCHEMBL15263214 | 0.77 | PDE4A (1.00) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| Zardaverine SCHEMBL29388700 | 0.77 | PDE4A (1.00) | PDE4DPDE4BPDE4APDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0553174-B1 | ARYLPYRIDAZINONES | BYK GULDEN LOMBERG CHEM FAB (DE) | 1998-07-08 | — | — | EP | disclosed |
| US-5376656-A | Arylpyridazinones | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1994-12-27 | — | — | US | disclosed |