SCHEMBL8633658

SCHEMBL8633658

CCCCc1nc(SC)c(OC(=O)O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 6/20 0.59
AGTR2 P50052 6/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8640736 0.91 AGTR2 (0.56) AGTR1AGTR2
SCHEMBL8637469 0.90 AGTR2 (0.54) AGTR1AGTR2
SCHEMBL8552028 0.87 AGTR1 (0.61) AGTR1AGTR2
SCHEMBL7617595 0.87 AGTR1 (0.76) AGTR1AGTR2
SCHEMBL7706065 0.86 AGTR1 (0.64) AGTR1AGTR2
SCHEMBL7701060 0.86 AGTR2 (0.80) AGTR1AGTR2
SCHEMBL8638034 0.86 AGTR2 (0.54) AGTR1AGTR2
SCHEMBL8552894 0.85 AGTR2 (0.62) AGTR1AGTR2
SCHEMBL7608200 0.84 AGTR1 (0.63) AGTR1AGTR2
SCHEMBL8554457 0.84 AGTR1 (0.57) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0855392-A2 Five-membered heterocycles having biphenylsulphonyl substituents, processes for the preparation thereof, their use as medicaments or diagnostic agent and medicaments containing them HOECHST AKTIENGESELLSCHAFT (DE) 1998-07-29 EP disclosed