Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 14/20 | 0.58 |
| ▸ | CA12 | O43570 | 12/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 6/20 | 0.50 |
| ▸ | CA1 | P00915 | 5/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632858 | 0.91 | PTGS2 (0.55) | CA9CA12MEN1KMT2APTGS2 | |
| SCHEMBL8633844 | 0.91 | CA9 (0.56) | CA9CA12CA2CA1PTGS2 | |
| SCHEMBL8631075 | 0.90 | CA9 (0.55) | CA9CA12MEN1KMT2ACA2 | |
| SCHEMBL8635029 | 0.89 | CA9 (0.52) | CA9CA12CA2CA1CHRNA7 | |
| SCHEMBL8631671 | 0.89 | CHRNA7 (0.50) | CA9CA12CA2CA1CHRNA7 | |
| SCHEMBL7772996 | 0.87 | MEN1 (0.59) | CA9CA12MEN1KMT2ACA2 | |
| SCHEMBL7773212 | 0.85 | MEN1 (0.57) | CA9CA12MEN1KMT2ACA2 | |
| SCHEMBL8630209 | 0.85 | PTGS2 (0.53) | CA9CA12PTGS2 | |
| SCHEMBL8628180 | 0.83 | CA9 (0.45) | CA9CA12CHRNA7PTGS2 | |
| SCHEMBL7779737 | 0.82 | MEN1 (0.67) | CA9CA12MEN1KMT2ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |