Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 12/20 | 0.55 |
| ▸ | CA12 | O43570 | 10/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 5/20 | 0.46 |
| ▸ | CA2 | P00918 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PTGIR | P43119 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633844 | 0.93 | CA9 (0.56) | CA9CA12SMN1; SMN2CA1CA2 | |
| SCHEMBL8635029 | 0.91 | CA9 (0.52) | CA9CA12CA1CA2PTGS2 | |
| SCHEMBL8631671 | 0.91 | CHRNA7 (0.50) | CA9CA12CA1CA2GAA | |
| SCHEMBL8631432 | 0.90 | PTGS2 (0.54) | CA9CA12MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8633767 | 0.90 | CA9 (0.58) | CA9CA12MEN1KMT2ACA1 | |
| SCHEMBL9877233 | 0.89 | MEN1 (0.56) | MEN1KMT2ASMN1; SMN2GAAPTGIR | |
| SCHEMBL7779615 | 0.85 | PTGIR (0.53) | CA9CA12CA1CA2PTGIR | |
| SCHEMBL8628180 | 0.85 | CA9 (0.45) | CA9CA12PTGS2 | |
| SCHEMBL7780667 | 0.83 | PTGS2 (0.51) | CA9CA12CA1CA2PTGIR | |
| SCHEMBL8632092 | 0.83 | ALDH1A1 (0.55) | CA9CA12SMN1; SMN2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |