SCHEMBL8633871

SCHEMBL8633871

O=C(Oc1ccccc1)C(=O)OC1CCN(c2ccncc2)CC1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 5/20 0.53
CYP2D6 P10635 3/20 0.53
TSHR P16473 3/20 0.53
HIF1A Q16665 3/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
ALDH1A1 P00352 1/20 0.53
MAPK1 P28482 1/20 0.53
HRH3 Q9Y5N1 2/20 0.51
CYP2C19 P33261 4/20 0.49
CYP3A4 P08684 3/20 0.49
F10 P00742 8/20 0.47
CYP1A2 P05177 2/20 0.46
ALOX15 P16050 2/20 0.46
ITGB3 P05106 2/20 0.44
ITGA2B P08514 2/20 0.44
LSS P48449 1/20 0.44
POLB P06746 1/20 0.44
MAPT P10636 1/20 0.44
F2 P00734 3/20 0.42
FFAR4 Q5NUL3 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7401896 0.76 HRH3 (0.62) CYP2C9CYP2D6TSHRHIF1ASMN1; SMN2
Hydrochloric Acid SCHEMBL8686214 0.76 HRH3 (0.50) CYP2C9CYP2D6TSHRHIF1ASMN1; SMN2
Hydrochloric Acid SCHEMBL6207497 0.75 HRH3 (0.61) CYP2C9CYP2D6TSHRHIF1ASMN1; SMN2
SCHEMBL8633876 0.75 HRH3 (0.49) CYP2C9CYP2D6TSHRHIF1ASMN1; SMN2
SCHEMBL2886329 0.74 ALDH1A1 (0.53) SMN1; SMN2ALDH1A1POLBELANE
Hydrochloric Acid SCHEMBL8632011 0.74 HRH3 (0.60) CYP2C9CYP2D6TSHRHIF1ASMN1; SMN2
SCHEMBL8686293 0.74 HRH3 (0.51) CYP2C9CYP2D6TSHRHIF1ASMN1; SMN2
SCHEMBL3406339 0.73 MAPT (0.55) CYP2C9TSHRSMN1; SMN2ALDH1A1HRH3
SCHEMBL3406337 0.73 CYP2C19 (0.55) CYP2C9TSHRSMN1; SMN2ALDH1A1MAPK1
SCHEMBL8636354 0.72 FAAH (0.46) CYP2C9CYP2D6TSHRHIF1ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5753659-A ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, ZENECA LIMITED (GB) 1998-05-19 US disclosed
US-5750754-A TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS ZENECA LIMITED (GB) 1998-05-12 US disclosed
US-5728701-A INHIBIT PLATELET AGGREGATION ZENECA LIMITED (GB) 1998-03-17 US disclosed