Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8634980 | 0.94 | CYP2C9 (0.46) | CYP2C9CYP2C19POLBALOX5PTGS1 | |
| SCHEMBL8758097 | 0.81 | CYP2C9 (0.68) | CYP2C9CYP2C19POLBMEN1KMT2A | |
| SCHEMBL9063248 | 0.79 | PTPN1 (0.58) | CYP2C9CYP2C19POLBALOX5SMN1; SMN2 | |
| SCHEMBL8757980 | 0.78 | CYP2C9 (0.51) | CYP2C9CYP2C19POLBSMN1; SMN2MAOB | |
| SCHEMBL8727310 | 0.78 | CYP2C9 (0.47) | CYP2C9CYP2C19 | |
| SCHEMBL10861821 | 0.77 | PKM (0.58) | POLBALOX5RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8636618 | 0.75 | CYP2C9 (0.54) | CYP2C9CYP2C19KMT2ACFTRALDH1A1 | |
| SCHEMBL850542 | 0.73 | SRD5A2 (0.62) | POLBALDH1A1 | |
| SCHEMBL8758970 | 0.72 | POLB (0.46) | CYP2C9CYP2C19POLBALOX5ALDH1A1 | |
| SCHEMBL8757958 | 0.72 | CYP2C9 (0.47) | CYP2C9CYP2C19CFTRSMN1; SMN2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717746-B1 | PHOSPHINIC ACID DERIVATIVES WITH ANTI-HYPER GLYCEMIC AND/OR ANTI-OBESITY ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-07-15 | — | — | EP | disclosed |
| EP-0717746-A1 | PHOSPHINIC ACID DERIVATIVES WITH ANTI-HYPER GLYCEMIC AND/OR ANTI-OBESITY ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-06-26 | — | — | EP | disclosed |
| WO-1995007284-A1 | PHOSPHINIC ACID DERIVATIVES WITH ANTI-HYPER GLYCEMIC AND/OR ANTI-OBESITY ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-03-16 | — | — | WO | disclosed |