SCHEMBL8635197

SCHEMBL8635197

Cc1cc(Cc2cc(C)cc(C(C)(C)C)c2OPCl)c(OCl)c(C(C)(C)C)c1

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HSPA5 P11021 1/20 0.46
CYP2C9 P11712 2/20 0.45
CYP2C19 P33261 2/20 0.45
HIF1A Q16665 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
CYP2D6 P10635 2/20 0.41
HSD17B10 Q99714 1/20 0.41
ALDH1A1 P00352 1/20 0.34
CA2 P00918 1/20 0.34
POLB P06746 1/20 0.34
TYR P14679 1/20 0.34
CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1777835 0.89 HSPA5 (0.53) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL3971595 0.79 HSPA5 (0.44) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
Hydrochloric Acid SCHEMBL28141949 0.73 SMN1; SMN2 (0.46) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL9329816 0.71 HSPA5 (0.51) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL20408073 0.71 HSPA5 (0.47) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL7918964 0.70 HSPA5 (0.50) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL15980586 0.69 HSPA5 (0.53) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL9330511 0.69 HSPA5 (0.49) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL28034278 0.68 SMN1; SMN2 (0.50) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2
SCHEMBL9356369 0.68 HSPA5 (0.51) HSPA5CYP2C9CYP2C19HIF1ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5712403-A CATALYST MITSUBISHI CHEMICAL CORPORATION (JP) 1998-01-27 US disclosed
US-5600032-A OLIGOMERIZATION OF A CONJUGATED ALKADIENE IN PRESENCE OFPALLADIUM, PHOSPHORUS COMPLEX MITSUBISHI CHEMICAL CORPORATION (JP) 1997-02-04 US disclosed